000			01779nam a22001937a 4500
999			_c4661 _d4661
005			20230127163010.0
008			230127b ||||| |||| 00| 0 eng d
020			_a9780670096039
082			_a615.309 _bCHI
100			_aChirmule, Narendra _910693
245			_aGood genes gone bad: _ba short history of vaccines and biologics
260			_bPenguin Random House India Pvt. Ltd. _aHaryana _c2021
300			_axxxvi, 202 p.
365			_aINR _b599.00
520			_aThe field of biotechnology has evolved over the past four decades, developing medicines which are curing diseases. But this journey of success has been tough and arduous, built upon the shoulders of major failures. Good Genes Gone Bad highlights seven such colossal failures in drug development-all of which culminated in the development of novel drugs-weaving together various analogies through the stories and thus allowing the reader to understand complex biological phenomena. These stories include treatment of medical conditions such as genetic clotting disorder (haemophilia), childhood-diarrhoea (rotavirus vaccine), preventing HIV infection, activation of the immune systems to treat cancer, gene therapy for treatment of diseases caused by gene-defects/mutations, cell therapy for treatment of leukaemias, and finally the success of Biocon’s approval of the first biologic drug for breast cancer. Written by the former R&D head of Biocon, India’s largest pharmaceutical company, Good Genes Gone Bad is a fascinating look at the complex world of medicine and drug development, providing the readers with a sense of magnitude of challenges and the extent of difficulty that it takes to make novel medicines.
650			_aBiologicals _911680
650			_aDrugs--Research _911681
942			_2ddc _cBK